[solved]-Hodgkin And Katz J Physiol I949 8 37 77 Investigated The Effects Of Different Ion Concentrations In The Fluid Surrounding Their Giant Squid Axons On Action Potentials They Found That The Mem 36917

Hodgkin and Katz (J. Physiol. (I949) 8, 37-77) investigated theeffects of different ion concentrations, in the fluid surroundingtheir giant squid axons, on action potentials. They found that themembrane permeability for K+ was 25 times greater than Na+.Temp: 37 C (remember to convert toKelvin)permeability of K+ =25permeability of Na+ = 1[Ko]=5 mM,[Ki]=150 mM [Nao]=150 mM, [Nai]=15 mM.a) Calculate the resting membrane potential for a neurongiven the parameters above.b) Calculate the membrane potential when the membrane is600vtimes more permeable for Na+ than K+(Hint you can use PNa=600 and PK=1). Thischange in relative permeability is seen during the activation ofvoltage-gated Na+ channelsc) The voltage calculated in question part b. would beobserved:a) Resting membrane potentialb) Hyperpolarization (undershoot)c) Depolarization (overshoot)d) Depolarization (rising phase belowovershoot)e) Repolarization (falling phaseovershoot)d) Describe the events associate with an action potential.Be sure to address which ion channels are open, closed, orinactive, the direction of ion movement, and the ion that ismoving.

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